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KMID : 0363420210350010048
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Journal of Korean Oriental Pediatrics
2021 Volume.35 No. 1 p.48 ~ p.62
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Review of Clinical Studies for Herbal Medicine Treatment on Acute Leukemia - Focusing on Studies from the China Academic Journal (CAJ)
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Kim Jeong-Eun
Jang Jin-Woo
Park Beom-Chan
Kim Ki-Bong
Cheon Jin-Hong
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Abstract
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Objectives The purpose of this study is to obtain knowledge from clinical studies conducted in China to examine the effectiveness of herb medicine in childhood acute leukemia.
Methods: We searched the randomized controlled trials (RCTs) with herbal medicine treatment on childhood acute leukemia from the ¡®CAJ¡¯, Chinese Academic Journal from China National Knowledge Infrastructure (CNKI). And then, demographic data, duration of illness, intervention, treatment period, outcome, adverse events, and composition of herbal medicine were analyzed for this study.
Result: 10 RCT studies were selected and analyzed. The control group were given western medicine therapy, the treatment group was given herbal medicine on the basis of the control group. The most commonly used herbal medicine were ôèæðú°Ô¸å·, ÜÍѨå·, ÜÍëäå·, üÀúìËäåÜå· in ¡®boosting vital force and driving out evil spirit (ݦïáËäÞ÷)¡¯ way to ¡®relieve heat (æðÔ¸)¡¯ and ¡®assist the vital force (ïáѨ)¡¯. In the treatment group, complete remission was significantly higher than control group and the decrease in TCM syndrome scores also showed significant effects. Adverse events were significantly lower in the treatment group.
Conclusions: Herbal medicine treatment on childhood acute leukemia can be suggested as a new treatment for children who have less response to the conventional therapy, and can supplement the limitations of the western medicine by increasing complete remission and reducing adverse events.
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KEYWORD
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Acute leukemia, Herbal medicine, Child, Randomized Controlled Trial, Review
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